Proof of Usefulness Report

Isomab Ltd.

Analysis completed on 1/28/2026

+315

Proof of Usefulness Score

Certified Problem Solver

Isomab Ltd is a verified, high-potential biotech spin-out from the University of Nottingham, developing novel isoform-specific antibodies (ISM-001) for peripheral arterial disease. While the project has secured significant traction via £7.5M (~$9.5M) in Series A funding (Feb 2024) and partnerships (Catalent), the submission itself is of very low quality. The input contains major inaccuracies, claiming a team size of 125 (reality: ~9) and stating 'most people have used my product' (false; the drug is pre-clinical). The score reflects the strong external evidence of scientific merit and investor backing, heavily penalized for the deceptive and erroneous submission details.

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Score Breakdown

Real World Utility+108.0

Audience Reach Impact+60.0

Technical Innovation+85.5

Evidence Of Traction+40.0

Market Timing Relevance+34.0

Functional Completeness+1.0

Subtotal+328.5

Usefulness Multiplierx0.96

Final Score+315

Project Details

Project URL

isomab.bio

Description

IsomAb is taking a different approach to identify, evaluate and develop isoform specific antibodies to treat disease where patients currently have limited or no treatment options. IsomAb is developing isoform specific antibodies and it has identified, using a combined bioinformatics/knowledge-based platform approach, ISM-001 which specifically inhibits the VEGF-A165b isoform of Vascular Endothelial Growth Factor-A (VEGF-A); based on 20 years of research by our two Founders, the evidence shows reducing serum levels of VEGF-A165b is key to ensuring new blood vessel formation in patients with ischemic disease.

Algorithm Insights

Market Position

Strong market validation with clear user adoption patterns

User Engagement

Documented reach suggests active user community

Technical Stack

Modern tech stack aligned with sponsor technologies

Recommendations to Increase Usefulness Score

Document User Growth

Provide specific metrics on user acquisition and retention rates

Showcase Revenue Model

Detail sustainable monetization strategy and current revenue streams

Expand Evidence Base

Include testimonials, case studies, and third-party validation

Technical Roadmap

Share development milestones and feature completion timeline