Proof of Usefulness Report

EnPlusOne Biosciences

Analysis completed on 2/4/2026

+639
Proof of Usefulness Score
Category Standard

EnPlusOne Biosciences is a high-potential Series B biotechnology company (approx. $46M raised) spun out of the Wyss Institute at Harvard. Their ezRNA™ platform addresses a critical bottleneck in RNA therapeutics manufacturing. However, the project submission itself was of extremely low quality, containing hallucinated tags ('film') and false traction claims ('most people have used my product'). The score reflects the high real-world value and capital backing of the actual company, severely penalized by the poor response quality and lack of substantiated user reach in the provided text.

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Score Breakdown

Real World Utility+230.0
Audience Reach Impact+15.0
Technical Innovation+171.0
Evidence Of Traction+212.5
Market Timing Relevance+95.0
Functional Completeness+2.5
Subtotal+726
Usefulness Multiplierx0.88
Final Score+639

Project Details

Project URL
Description
EnPlusOne Biosciences is a biotechnology company developing a novel enzymatic-based RNA synthesis platform called ezRNA™. This platform aims to address limitations in current chemical synthesis methods for RNA therapeutics, enabling more sustainable and scalable production. The company's technology can incorporate a diverse array of natural and modified nucleotides, paving the way for the development of next-generation RNA drugs, vaccines, and gene-editing therapies.

Algorithm Insights

Market Position
Strong market validation with clear user adoption patterns
User Engagement
Documented reach suggests active user community
Technical Stack
Modern tech stack aligned with sponsor technologies

Recommendations to Increase Usefulness Score

Document User Growth

Provide specific metrics on user acquisition and retention rates

Showcase Revenue Model

Detail sustainable monetization strategy and current revenue streams

Expand Evidence Base

Include testimonials, case studies, and third-party validation

Technical Roadmap

Share development milestones and feature completion timeline