Proof of Usefulness Report

AAVantgarde Bio

Analysis completed on 2/4/2026

+646
Proof of Usefulness Score
Category Standard

AAVantgarde Bio is a verified clinical-stage biotechnology company with over $200M in funding (Series A and B), developing high-utility gene therapies for Stargardt disease and Usher syndrome type 1B. Despite the low-quality submission (incorrect claims of 'everyone' as audience and 'most people' as users), the underlying project demonstrates exceptional real-world utility, technical innovation, and significant traction through institutional backing and regulatory milestones (Orphan Drug Designation). The score reflects the high value of the entity, adjusted for the discrepancy in submission quality.

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Score Breakdown

Real World Utility+237.5
Audience Reach Impact+50
Technical Innovation+142.5
Evidence Of Traction+180
Market Timing Relevance+90
Functional Completeness+2.5
Subtotal+702.5
Usefulness Multiplierx0.92
Final Score+646

Project Details

Project URL
aavantgarde.com
Description
AAVantgarde Bio is a clinical-stage biotechnology company focused on developing next-generation gene therapies for inherited retinal diseases. The company leverages proprietary Adeno-Associated Viral (AAV) vector platforms to overcome limitations in gene delivery capacity, aiming to restore visual function and halt disease progression. AAVantgarde Bio originated from research activities at the Telethon Institute of Genetics and Medicine (TIGEM) and has secured significant funding to advance its clinical trials.

Algorithm Insights

Market Position
Strong market validation with clear user adoption patterns
User Engagement
Documented reach suggests active user community
Technical Stack
Modern tech stack aligned with sponsor technologies

Recommendations to Increase Usefulness Score

Document User Growth

Provide specific metrics on user acquisition and retention rates

Showcase Revenue Model

Detail sustainable monetization strategy and current revenue streams

Expand Evidence Base

Include testimonials, case studies, and third-party validation

Technical Roadmap

Share development milestones and feature completion timeline